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GATA4 (6H10) Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 252901

GATA4 (6H10) Antibody

GATA4 (GATA binding protein 4) is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene e, Xenopus/Amphibian,pression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1/2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations have been associated with cardiac septal defects.

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SPECIFICATIONS

Catalog Number

252901

Size

0.1 ml

Applications

WB

Reactivities

Hum, Mouse

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of human GATA4 e, Xenopus/Amphibian,pressed in E. coli.

Isotype

Mouse IgG2b

Accession

P43694

Clonality

6H10

Additional Info

Transcription factor GATA-4; GATA-binding factor 4; GATA4

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