Reactivities: | Human, Mouse |
Presku: | AAP40188 |
Size: | 100ug |
Weight: | 36kDa |
Gene: | 14433 |
Format: | Lyophilized powder |
Target: | Gapdh has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Gapdh also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. |
Alternative names: | Gapd; MGC102544; MGC102546; MGC103190; MGC103191; MGC105239 |