Home  >  Products  >  GAP-43 Antibody
GAP-43 Antibody

GAP-43 Antibody

Cat no: 250658


Supplier: ABBIOTEC
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
GAP-43 (Growth associated protein-43, neuromodulin) is a cytoplasmic a, Xenopus/Amphibian,onal membrane protein that is involved in the neuronal outgrowth and synaptic plasticity of developing and regenerating neurons . Palmitoylated GAP-43 attaches to the membrane via lipid rafts, while the unmodified form is a component of the centrosome. GAP-43 binds to calmodulin in the absence of Ca++ and functions as a substrate for PKC in the nerve growth factor (NGF) signaling pathway. Gap-43 functions as an adapter protein, binding and interacting with several molecules including PKC,PorcineIP2, actin, calmodulin, spectrin,Porcinealmitate, synaptophysin, amyloid, and tau. A lack of GAP-43 or phosphorylation leads to severe neuronal developmental or learning disfunction.
Catalogue number: 250658
Reactivities: Human, Mouse, Bovine, Chicken/Bird, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P17677
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GAP-43.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit IgG
Additional info: GAP-43; Growth-associated protein 43; Neuromodulin; A, Xenopus/Amphibian,onal membrane protein GAP-43; PP46; Neural phosphoprotein B-50; GAP43