67 kDa glutamic acid decarbo, Xenopus/Amphibian,ylase (GAD-67) catalyzes the production of GABA, the main inhibitory neurotransmitter in the central nervous system. Defects in GAD-67 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1), a non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay,Mouse,ental retardation and sometimes epilepsy can be part of the clinical picture.