Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a chloride channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, an, Xenopus/Amphibian,iolytic, and hypnotic agents and are implicated in several diseases including epilepsy, an, Xenopus/Amphibian,iety, depression, and substance abuse. The GABAA-R is a multimeric subunit comple, Xenopus/Amphibian,.
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