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Fzr1 (fizzy/cell division cycle 20 related 1 (Drosophila)) Blocking Peptide (the N terminal of Fzr1)(100ug)

Fzr1 (fizzy/cell division cycle 20 related 1 (Drosophila)) Blocking Peptide (the N terminal of Fzr1)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-FZR1 Antibody(ARP51279_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP51279
Size: 100ug
Weight: 55kDa
Gene: 51343
Format: Lyophilized powder
Target: FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Alternative names: CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1; KIAA1242
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