Presku: | AAP30320 |
Size: | 100 ug |
Weight: | 54kDa |
Gene: | 4303 |
Format: | Lyophilized powder |
Target: | FOXO4 is transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. The protein can down-regulate expression of HIF1A and suppress hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias. |
Alternative names: | AFX; AFX1; MGC120490; MLLT7 |