FO, Xenopus/Amphibian,A2 (Forkhead bo, Xenopus/Amphibian, A2) is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FO, Xenopus/Amphibian,A2 has been linked to sporadic cases of maturity-onset diabetes of the young.