FMR1 (4G9) Antibody

FMR1 (Fragile , Xenopus/Amphibian, mental retardation protein 1) is an RNA-binding protein. FMR1 associates with polyribosomes and is a likely component of a messenger ribonuclear protein (mRNP) particle The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an e, Xenopus/Amphibian,pansion to 55-230 repeats is the cause of fragile , Xenopus/Amphibian, syndrome. E, Xenopus/Amphibian,pansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs.