Reactivities: | Human |
Presku: | AAP65168 |
Size: | 100ug |
Weight: | 12kDa |
Gene: | 2280 |
Format: | Lyophilized powder |
Target: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. |
Alternative names: | FKBP-12; FKBP1; FKBP12; FKBP12C; PKC12; PKCI2; PPIASE |