FITC anti-rat CD49d

CD49d is a 150 kD glycoprotein, also known as integrin alpha4 or VLA-4 alpha chain. It is expressed as a heterodimer with either of two beta chains, beta1 or beta7. The alpha4beta1 integrin (also known as VLA-4, CD49d/CD29) is expressed on peripheral T and B lymphocytes, thymocytes, and monocytes, while the alpha4beta7 integrin (also known as LPAM-1) is expressed on peripheral lymphocytes. The alpha4beta1 and alpha4beta7 integrins mediate cell-cell and cell-matrix interactions by interacting with the ligands CD106 (VCAM-1), MAdCAM-1, and fibronectin. Soluble MRalpha4-1 antibody can partially inhibit in vitro binding of VCAM-1 and mast cells to fibronectin and inhibit mast cell degranulation. Immobilized MRalpha4-1 antibody can enhance mast cell degranulation in vitro.

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SPECIFICATIONS

Catalog Number

200103

Size

50 microg

Applications

FC

Hosts

Mouse

Reactivities

Rat

Clone

MRalpha4-1

Antigen

RBL-2H3 rat basophilic leukemia cell line

Gene Id

16401

Isotype

Mouse IgG2a, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ? 0.25 microg per 106 cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

Integrin alpha4 chain, alpha4 integrin, VLA-4 alpha chain, integrin a4

Regulatory Status

RUO