FITC anti-mouse TCR Vgamma1.1/Cr4

T cell receptor (TCR) is a heterodimer consisting of an alpha and beta chain (TCR alpha/beta) or a gamma and delta chain (TCR gamma/delta). TCR associates with CD3 to form a CD3/TCR complex. The CD3/TCR plays a key role in antigen recognition, signal transduction, and T cell activation. TCR Vgamma1.1 (Garman nomenclature) is also called TCR Vgamma1 (Tonegawa nomenclature). The Vgamma1 gene almost exclusively rearranges to the Jgamma4-Cgamma4 gene. Vgamma1- Jgamma4-Cgamma4 expressing cells constitute a major population of gamma/delta T cells in thymus and peripheral lymphoid organs in adult mice, but they are only composed of a minor population of gamma/delta T cells during fetal and early postnatal life. Vgamma1 T cell development can happen in thymus-dependent and thymus-independent manners. Further studies have shown that the antibody 2.11 recognized epitote is located in Cr4 domain.

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SPECIFICATIONS

Catalog Number

141104

Size

100 microg

Applications

FC

Reactivities

Mouse

Clone

2.11

Antigen

T3.13.1 T-cell hybridoma cell line

Gene Id

110067

Isotype

Armenian hamster IgG

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?0.25 microg per million cells in 100 microl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C and protected from prolonged exposure to light. Do not freeze.

Alternative Names

T cell receptor Vgamma 1.1, TCR Vgamma1

Regulatory Status

RUO