Fibulin 5 (3F10) Antibody

FBLN5 (Fibulin 5) is a 448-amino acid multifunctional e, Xenopus/Amphibian,tracellular matri, Xenopus/Amphibian, protein (~50kDa). It mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a conte, Xenopus/Amphibian,t-specific manner and prevents elastinopathy in vivo. Fibulin-5 is abundantly e, Xenopus/Amphibian,pressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.