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Fibulin 3 Antibody (OAPB00902)

Fibulin 3 Antibody (OAPB00902)

Fibulin 3, also known as epidermal growth factor (EGF)-containing fibulin-like extracellular matrix protein 1 (EFEMP1), is a member of the fibulin family of extracellular glycoproteins, a group of proteins that are widely distributed and frequently associated with vascular and elastic tissues. The fibulin proteins typically contain a tandem array of EGF-like repeats and a fibulin-type COOH-terminal module. Aberrant accumulation of Fibulin 3 in the endoplasmic reticulum of retinal pigment epithelial cells has been shown to be associated with inherited forms of macular degeneration, but the loss of Fibulin 3 expression does not lead to macular degeneration but rather the appearance of hernias due to a reduction of elastic fibers of fascial connective tissue. Recent experiments have shown that expression of Fibulin 3 promotes tumor growth and may thus be a therapeutic target. At least three isoforms of Fibulin 3 are known to exist. This antibody is predicted to not cross-react with other Fibulin proteins.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, ICC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Presku

OAPB00902

Target

EGF-containing fibulin-like extracellular matrix protein 1

Alternative Names

Fibulin 3; FBLN3; EGF-containing fibulin-like extracellular matrix protein 1; EFEMP1; DHRD; DRAD; FBNL; MLVT; MTLV; S1-5; FIBL-3

SUPPLIER INFO

Aviva Systems Biology Incorporated

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