Fibrinogen (2F4) Antibody

Fibrinogen, the precursor of fibrin, is the coagulable protein in the blood plasma of vertebrates. Fibrinogen consists as a dimer of 3 pairs of non-identical chains Aa (Mr= 66,800), Bb (Mr= 52,000) and g (Mr=46,500) cross-linked by disulfide bonds in their N-terminal segments. The molecule has 2 terminal D domains and one central E domain, all three domains are separated when fibrinogen is degradated by plasmin. MW is 340 kDa. Concentration in human plasma is 2-3 mg/ml. This antibody has specificity for human fibrinogen degradation product D-fragment. The antibody reacts with both purified D-monomer, fibrinogen and factor VIII.