Reactivities: | Human |
Presku: | AAP54523 |
Size: | 100ug |
Weight: | 59kDa |
Gene: | 2268 |
Format: | Lyophilized powder |
Target: | This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
Alternative names: | FLJ43153; MGC75096; SRC2; c-fgr; c-src2; p55c-fgr; p58c-fgr |