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FGFR1 Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250651

FGFR1 Antibody

FGFR1 (Basic fibroblast growth factor receptor 1) is a membrane receptor for basic fibroblast growth factor (FGF2) and for acidic fibroblast growth factor (FGF1). Binding of FGF and heparin leads to receptor dimerization and autophosphorylation at 7 tyrosine residues in the cytoplasmic tail. Phosphorylation of tyrosine 653 and 654 are important for catalytic activity while other sites may provide docking sites for downstream signaling components such as Crk and PLCgamma. FGFR1 also interacts with SHBovine, KLBovine, FGF23, GRB10. FGFR1 activation influences mitogenesis and differentiation of various cell types. Mutations and chromosomal aberrations are associated with various disorders including Pfeiffer Syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, stem cell leukemia lymphoma syndrome and stem cell myeloproliferative disorder.

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SPECIFICATIONS

Catalog Number

250651

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human FGFR1.

Isotype

Rabbit Ig

Accession

P11362

Additional Info

FGFR1; Fibroblast growth factor receptor 1; Basic fibroblast growth factor receptor 1; FGFR-1; bFGF-R-1; Proto-oncogene c-Fgr; Fms-like tyrosine kinase 2; c-fgr; CD331; FLT-2; FGFBR; FLG; FLT2

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