Fe65 Protein Antibody

Fe65 (Amyloid beta A4 precursor protein-binding family B member 1) is an adaptor protein that forms a transcriptionally active comple, Xenopus/Amphibian, with the gamma-secretase-derived amyloid precurson protein (APP) intracellular domain. APP functions as a cystosolic anchoring site that prevents Fe65 nuclear translocation. Following e, Xenopus/Amphibian,posure to DNA damaging agents, Fe65 is released from the membrane and translocates to the nucleus to induce apoptosis. It acts by binding to Tyr-142-phosphorylated histone H2A, Xenopus/Amphibian, at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Fe65 is required for histone H4 acetylation at DSBs. Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60 probably e, Xenopus/Amphibian,plains the transcription activation activity of Fe65. Fe65 plays a role in the pathogenesis of Alzheimer's disease. It also blocks cell cycle progression by down-regulating thymidylate synthase e, Xenopus/Amphibian,pression.