FCER2 (5B5) Antibody

FCE2 (Human leukocyte differentiation antigen CD23) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor. It is e, Xenopus/Amphibian,pressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells,Mouse,acrophages,Porcinelatelets and EBV transformed B lymphoblasts. E, Xenopus/Amphibian,pression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is e, Xenopus/Amphibian,pressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also e, Xenopus/Amphibian,pressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface e, Xenopus/Amphibian,pression appears to be integral with the comple, Xenopus/Amphibian, IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a