Reactivities: | Human |
Presku: | AAP53775 |
Size: | 100ug |
Weight: | 40kDa |
Gene: | 79791 |
Format: | Lyophilized powder |
Target: | FBXO31 is the component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. FBXO31 specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. |
Alternative names: | DKFZP434B027; DKFZp434J1815; FBX14; FBXO14; FLJ22477; Fbx31; MGC15419; MGC9527; pp2386 |