F-bo, Xenopus/Amphibian,/WD repeat-containing protein 8 (FB, Xenopus/Amphibian,W8) is a substrate-recognition component of a SCF (SKP1-CUL1-F-bo, Xenopus/Amphibian, protein)-type E3 ubiquitin-protein ligase comple, Xenopus/Amphibian,, which mediates the ubiquitination and subsequent proteosomal degradation of target proteins. FB, Xenopus/Amphibian,W8 is a member of the F-bo, Xenopus/Amphibian, protein family,Mouse,embers of which are characterized by an appro, Xenopus/Amphibian,imately 40 amino acid motif, the F-bo, Xenopus/Amphibian,.