FASLG Human - Recombinant Human FAS Ligand (2ug)

Product Introduction: The type II transmembrane protein FASLG is a member of the tumor necrosis factor (TNF) superfamily. A fas ligand/receptor interaction has a significant part in the regulation of the immune system and the advancement of cancer. FASLG is expressed on the activated T cell surface as a nondisulfidelinked homotrimer. FASLG binding to Fas/CD95/TNFRSF6 on a nearby cell prompts apoptosis in the Fas expressing cell. FASLG is released from the cell surface by metalloproteinases as a soluble molecule that stays trimeric and is able to bind with Fas, but its capability to activate apoptosis is radically reduced. In addition, FASLG binds to DcR3 - a soluble trap receptor with no signal transduction capabilities. Flawed Fas-mediated apoptosis causes oncogenesis in addition to drug resistance in existing tumors. Constitutive expression of FASLG in a variety of tumors enables their immune evasion. Both mouse and human FASLG are active on mouse and human cells.
Product Description: Recombinant Human FAS Ligand produced in HEK293 cells is a non-glycosylated, polypeptide chain containing 147 amino acids (134-281a.a). FASLG is fused to a 6 amino acid His-tag at N-terminus and purified by proprietary chromatographic techniques.

Prices direct from Aviva Systems Biology Incorporated

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Size

2ug

Format

Sterile Filtered colorless solution.

Presku

OOPA00062

Alternative Names

Fas ligand (TNF superfamily; member 6); APT1LG1; FASL; TNFSF6; CD178; tumor necrosis factor (ligand) superfamily member 6; Apoptosis antigen ligand; Fas antigen ligand; APTL; CD95-L.