Protein FAM3A (FAM3A) is a member of the FAM3 family. The FAM3 proteins were identified based on structural, but not sequence, homology to short chain cytokines including IL-2, IL-4 and GM-CSF. FAM3 proteins are four heli, Xenopus/Amphibian, bundle cytokines with four conserved cysteines in all members (FAM3A-D). FAM3B (also known as PANDER, for pancreatic derived factor) is highly e, Xenopus/Amphibian,pressed in alpha and beta cells of the pancreas and is being investigated as a potential contributor to beta cell death and development of type I diabetes.