Supplier:
Aviva Systems Biology IncorporatedFAM175A (family with sequence similarity 175, member A ) Blocking Peptide (the C terminal of FAM175A)(100ug)
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SPECIFICATIONS
Size
100ug
Reactivities
Hum
Format
Lyophilized powder
Presku
AAP65319
Target
FAM175A is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
Weight
47kDa
Gene Id
84142
Alternative Names
ABRA1; CCDC98; FLJ11520; FLJ12642; FLJ13614
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