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FADD Antibody

FADD Antibody

Cat no: 251168


Supplier: ABBIOTEC
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FAS-associated death domain protein (FADD) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling comple, Xenopus/Amphibian, (DISC) performs caspase-8 proteolytic activation. FADD is involved in interferon-mediated antiviral immune response,Porcinelaying a role in the positive regulation of interferon signaling. Defects in FADD are the cause of recurrent infections associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM). IEHDCM is a condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4-CD8-TCR-alpha-beta+ T-cell counts, and elevated IL10 and FASL levels.
Catalogue number: 251168
Reactivities: Human, Mouse, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: Q13158
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human FADD.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
P type: Rabbit Polyclonal Antibody
Isotype: Rabbit Ig
Additional info: FADD; Protein FADD; Fas-associated protein with death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Mediator of receptor induced to, Xenopus/Amphibian,icity; Growth-inhbiting gene 3 protein; MORT1