Reactivities: | Human |
Presku: | AAP60035 |
Size: | 100ug |
Weight: | 44kDa |
Gene: | 2150 |
Format: | Lyophilized powder |
Target: | Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. |
Alternative names: | GPR11; PAR2 |