Epidermal Growth Factor (EGF), human, active

EGF is a polypeptide growth hormone which plays an important role in the regulation of growth, proliferation, and differentiation of a wide range of cells by binding to its receptor EGFR (epidermal growth factor receptor). Through its binding to cell surface receptors, EGF activates an extensive network of signal transduction pathways that include activation of the PI3K/AKT, RAS/ERK and JAK/STAT pathways. The full-length human EGF was expressed in E.coli and highly purified by the propriety chromatographic procedures. This product has the same amino acid sequence with the mature human EGF (6.35 kDa) and has no tag attached. Applications 1. EGF is commonly used as a supplement in serum-free or reduced serum media for culture of mammalian cells. 2. Studies of the human EGF receptor, transmembrane signaling and protein phosphorylation 3. Western blotting control for anti-EGF antibodies