Supplier:
Aviva Systems Biology IncorporatedEIF2AK1 antibody - N-terminal region (ARP42405_P050)
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SPECIFICATIONS
Size
50ug
Applications
IHC, WB
Hosts
Rabbit
Reactivities
Hum, Mouse, Rat, Bov, Can, Ch/Bird, Rabbit, ZF/Fish
Format
Lyophilized powder
Presku
ARP42405_P050
Target
EIF2AK1 acts at the level of translation initiation to downregulate protein synthesis in response to stress. The protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene.The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme. Sequence Note: The sequence AF181071.1 is a chimeric mRNA clone. Only the heme-regulated initiation factor 2-alpha kinase region was propagated into this RefSeq record.
Weight
71kDa
Gene Id
27102
Alternative Names
HRI; KIAA1369; HCR
SUPPLIER INFO
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