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EGLN3 (egl nine homolog 3 (C. elegans)) Blocking Peptide (100ug)

EGLN3 (egl nine homolog 3 (C. elegans)) Blocking Peptide (100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-EGLN3 antibody (Catalogue #: ARP52402_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Presku: AAP52402
Size: 100 ug
Weight: 27kDa
Gene: 112399
Format: Lyophilized powder
Target: EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
Alternative names: FLJ21620; HIFPH3; MGC125998; MGC125999; PHD3
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