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EGFRvIII Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250632

EGFRvIII Antibody

Epidermal growth factor receptor (EGFR) is a receptor for EGF and for various members of the EGF family such as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. EGFR is involved in the control of cell growth and differentation. Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor comple, Xenopus/Amphibian,, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis and cell proliferation. EGFRvIII has an 801-bp in-frame deletion resulting in a shorter e, Xenopus/Amphibian,tracellular domain (aa 6-273 are deleted) with generation of a glycine residue at the fusion point. EGFRvIII is tumor specific and is not e, Xenopus/Amphibian,pressed in normal human tissues. Defects in EGFR are associated with lung cancer.

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SPECIFICATIONS

Catalog Number

250632

Size

0.1 mg

Applications

WB

Reactivities

Hum

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human EGFRvIII.

Isotype

Rabbit Ig

Accession

P00533

Additional Info

Epidermal growth factor receptor; receptor tyrosine-protein kinase ErbB-1; EGFR; ERBB1; EGFRvIII; EGFR variant III

SUPPLIER INFO

ABBIOTEC

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