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DYRK2 Antibody (OAPB01277)

DYRK2 Antibody (OAPB01277)

DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Presku

OAPB01277

Target

Dual-specificity tyrosine phosphorylation-regulated kinase 2

Alternative Names

Dual-specificity tyrosine phosphorylation-regulated kinase 2

SUPPLIER INFO

Aviva Systems Biology Incorporated

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