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Dyrk1a (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a) Blocking Peptide (the N terminal of Dyrk1a)(100ug)

Dyrk1a (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a) Blocking Peptide (the N terminal of Dyrk1a)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-DYRK1A Antibody(ARP45797_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP45797
Size: 100ug
Weight: 85kDa
Gene: 1859
Format: Lyophilized powder
Target: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
Alternative names: DYRK; DYRK1; HP86; MNB; MNBH
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