Supplier:
Aviva Systems Biology IncorporatedDUT Protein Lysate (GST tagged) (Expressed in bacteria) (200ug)
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SPECIFICATIONS
Size
200ug
Presku
APL10341
Target
DUT is an essential enzyme of nucleotide metabolism. This protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death.
Weight
42
Gene Id
1854
Alternative Names
dUTPase; FLJ20622
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