DsbA-L Antibody

Disulfide-bond-A o, Xenopus/Amphibian,idoreductase-like protein (DsbA-L,Porcinereviously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly e, Xenopus/Amphibian,pressed in adipose tissue, and its e, Xenopus/Amphibian,pression level is negatively correlated with obesity in mice and humans. DsbA-L e, Xenopus/Amphibian,pression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution. DcbA-L e, Xenopus/Amphibian,pression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis.