Reactivities: | Human |
Presku: | AAP51955 |
Size: | 100ug |
Weight: | 49kDa |
Gene: | 1801 |
Format: | Lyophilized powder |
Target: | Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]). |
Alternative names: | DPH2L; DPH2L1; FLJ33211; OVCA1 |