

Supplier:
Aviva Systems Biology IncorporatedDNMT3B (DNA (cytosine-5-)-methyltransferase 3 beta) Blocking Peptide (the middle region of protein) (100ug)
Prices direct from Aviva Systems Biology Incorporated
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SPECIFICATIONS
Size
100 ug
Format
Lyophilized powder
Presku
AAP49124
Target
DNMT3B is required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. DNMT3B may preferentially methylate nucleosomal DNA within the nucleosome core region. DNMT3B may function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. DNMT3B seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, DNMT3B is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
Weight
86kDa
Gene Id
1789
Alternative Names
ICF; M.HsaIIIB
Applications
ELISA
Hosts
Mouse
Reactivities
Rat
Applications
ELISA
Hosts
Mouse
Applications
FC
Hosts
Mouse
Reactivities
Hum
Applications
ELISA, WB
Hosts
Mouse
Reactivities
Hum
Applications
ELISA, IHC
Hosts
Mouse
Reactivities
Hum
Applications
ELISA
Hosts
Mouse
Reactivities
Hum
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