Home  >  Products  >  Dnmt1 (DNA methyltransferase (cytosine-5) 1) Blocking Peptide (the N terminal of Dnmt1)(100ug)
Dnmt1 (DNA methyltransferase (cytosine-5) 1) Blocking Peptide (the N terminal of Dnmt1)(100ug)

Dnmt1 (DNA methyltransferase (cytosine-5) 1) Blocking Peptide (the N terminal of Dnmt1)(100ug)

Supplier: Aviva Systems Biology Incorporated
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
This is a synthetic peptide designed for use in combination with anti-Dnmt1 Antibody(ARP37033_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Mouse
Presku: AAP37033
Size: 100ug
Weight: 183kDa
Gene: 13433
Format: Lyophilized powder
Target: Dnmt1 methylates CpG residues.Dnmt1 preferentially methylates hemimethylated DNA. Dnmt1 associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance.Dnmt1 associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones.Dnmt1 mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, Dnmt1 is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Alternative names: Cxxc9; Dnmt; Dnmt1o; MTase; Met-1; Met1; MommeD2
See Full Product Listings >