
Supplier:
Aviva Systems Biology IncorporatedDnmt1 (DNA methyltransferase (cytosine-5) 1) Blocking Peptide (the N terminal of Dnmt1)(100ug)
Prices direct from Aviva Systems Biology Incorporated
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SPECIFICATIONS
Size
100ug
Reactivities
Mouse
Format
Lyophilized powder
Presku
AAP37033
Target
Dnmt1 methylates CpG residues.Dnmt1 preferentially methylates hemimethylated DNA. Dnmt1 associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance.Dnmt1 associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones.Dnmt1 mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, Dnmt1 is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
Weight
183kDa
Gene Id
13433
Alternative Names
Cxxc9; Dnmt; Dnmt1o; MTase; Met-1; Met1; MommeD2
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