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DLK1 (Human) cDNA (1ug)

DLK1 (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human DLK1 is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-DLK1 polyclonal antibody.
Presku: ANA10571
Size: 1ug
Gene: 8788
Target: This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
Alternative names: DLK; FA1; ZOG; pG2; PREF1; Pref-1; Delta1
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