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Dkk2 (dickkopf homolog 2 (Xenopus laevis)) Blocking Peptide (the middle region of Dkk2)(100ug)

Dkk2 (dickkopf homolog 2 (Xenopus laevis)) Blocking Peptide (the middle region of Dkk2)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Dkk2 Antibody (ARP55047_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Mouse
Presku: AAP55047
Size: 100ug
Weight: 28kDa
Gene: 56811
Format: Lyophilized powder
Target: Dkk2 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease.
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