Dehydroepiandrosterone (5-DHEA) is an endogenous natural steroid hormone. It is the major secretory steroidal product of the adrenal glands and is also produced by the gonads and the brain. DHEA has been implicated in a broad range of biological effects in humans and other mammals. Dehydroepiandrosterone sulfate (DHEAS) is the sulfated version of DHEA. This conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestine. In the blood,Mouse,ost DHEA is found as DHEAS with levels that are about 300 times higher than those of free DHEA.