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Desmin (10H7) Antibody

Desmin (10H7) Antibody

Cat no: 252674


Supplier: ABBIOTEC
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Desmin is a class-III intermediate filament found in muscle cells. In adult striated muscle desmin forms a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Defects in desmin are the cause of myopathy myofibrillar desmin-related (MFM-DES), also known as desmin-related myopathy (DRM). DRM is a neuromuscular disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure and by myofibrillar destruction with intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells.
Catalogue number: 252674
Reactivities: Human
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P17661
Antigen: Purified recombinant fragment of Desmin e, Xenopus/Amphibian,pressed in E. coli.
Format: Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Mouse Monoclonal Antibody
Isotype: Mouse IgG1
Clonality: 10H7D2
Additional info: Desmin; DES