Despiramine is a tricyclis antidepressant (TCA) which inhibits the reuptake of norepinephrine, to a lesser e, Xenopus/Amphibian,tant, serotonin. Desipramine is used to treat depression, but is not usually a fist line treatment due to the effectiveness and less severe side effects of SSRI antidepressants. Desipramine is used to treat depression, attention deficit hyperactivity disorder, and cocaine withdrawal. Caution is used when prescribing this medication as sever side-effects may occur, including cardiac arrhythmia.