DD, Xenopus/Amphibian,58 Antibody

Probable ATP-dependent RNA helicase DD, Xenopus/Amphibian,58 (DD, Xenopus/Amphibian,58) is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, DD, Xenopus/Amphibian,58 triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-Bovine, IRF3 and IRF7 and the induction of the e, Xenopus/Amphibian,pression of antiviral cytokines such as IFN-beta and RANTES (CCL5). DD, Xenopus/Amphibian,58 detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). DD, Xenopus/Amphibian,58 is essential for the production of interferons in response to RNA viruses including paramy, Xenopus/Amphibian,oviruses, influenza viruses, Japanese encephalitis virus and HCV.