Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. Cytokeratins form a comple, Xenopus/Amphibian, network e, Xenopus/Amphibian,tending from the nucleus to the cell membrane. This network is involved in cellular communication and cytoplasmic organization. Defects in cytokeratin-5 are implicated in numerous skin diseases, including pidermolysis bullosa simple, Xenopus/Amphibian, Dowling-Meara type and Dowling-Degos disease.