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CYP1A1 (Human) cDNA (1ug)

CYP1A1 (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human CYP1A1 is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-CYP1A1 polyclonal antibody.
Presku: ANA10762
Size: 1ug
Gene: 1543
Target: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
Alternative names: AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
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