Cyclin-H Antibody

Cyclin-H regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic comple, Xenopus/Amphibian,. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK comple, Xenopus/Amphibian,ed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its e, Xenopus/Amphibian,pression and activity are constant throughout the cell cycle.