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Cyclin D1 Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 252030

Cyclin D1 Antibody

G1/S-specific cyclin-D1 (cyclin D1) is essential for the control of the cell cycle at the G1/S (start) transition. Cyclin D1 interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme comple, Xenopus/Amphibian,. The cyclin subunit imparts substrate specificity to the comple, Xenopus/Amphibian,. Cyclin D1 interacts with FB, Xenopus/Amphibian,O4 and CDKN1B. Cyclin D1 is ubiquitinated,Porcinerimarily as 'Lys-48'-linked polyubiquitination, by a SCF (SKP1-CUL1-F-bo, Xenopus/Amphibian, protein) ubiquitin-protein ligase comple, Xenopus/Amphibian, containing FB, Xenopus/Amphibian,O4 and CRYAB. Defects in cyclin D1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia.

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SPECIFICATIONS

Catalog Number

252030

Size

0.1 mg

Applications

WB

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human cyclin D 1.

Isotype

Rabbit Ig

Accession

P24385

Additional Info

Cyclin D1; G1/S-specific cyclin-D1; PRAD1 oncogene; BCL-1 oncogene; BCL1; PRAD1

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