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Cyclin D1 Antibody

Cyclin D1 Antibody

Cat no: 251740


Supplier: ABBIOTEC
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G1/S-specific cyclin-D1 (cyclin D1) is a regulatory component of the cyclin D1-CDK4 (DC) comple, Xenopus/Amphibian, that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F comple, Xenopus/Amphibian, and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Defects in cyclin D1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia.
Catalogue number: 251740
Reactivities: Human, Mouse, Rabbit
Applications: Immunohistochemistry
Size: 0.1 mg
Accession: P24385
Antigen: Recombinant human cyclin D1 protein.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type: Mouse Monoclonal Antibody
Isotype: Mouse IgG2a
Additional info: Cyclin D1; G1/S-specific cyclin-D1; PRAD1 oncogene; BCL-1 oncogene; BCL1; PRAD1