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Cyclin C Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 250619

Cyclin C Antibody

Cyclin-C (CCNC) forms the CDK8 module with CDK8,Mouse,ED12,Mouse,ED13, which decreases transcriptional activation when combined with the Mediator comple, Xenopus/Amphibian,. The Mediator comple, Xenopus/Amphibian, is a large protein comple, Xenopus/Amphibian, composed of almost 30 different MED proteins that regulates transcription of nearly all RNA polymerase II (RNApII)-dependent genes, conveying information from gene-specific regulatory proteins. Mediator serves as a scaffold for the assembly of the functional preinitiation comple, Xenopus/Amphibian, that includes RNApII. Cyclin-C-bound CDK8 phosphorylates the C-terminal domain of the large subunit of RNApII, inhibiting the formation of a transcription initiation comple, Xenopus/Amphibian,. Cyclin-C is phosphorylated upon DNA damage,Porcinerobably by ATM or ATR.

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SPECIFICATIONS

Catalog Number

250619

Size

0.1 mg

Applications

IHC

Reactivities

Hum, Mouse, Bov, Can, Ch/Bird, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

P Type

Rabbit Polyclonal Antibody

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cyclin C.

Isotype

Rabbit IgG

Accession

P24863

Additional Info

Cyclin-C; Cyclin C; SRB11; CCNC

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