Cyclin C Antibody

Cyclin-C (CCNC) forms the CDK8 module with CDK8,Mouse,ED12,Mouse,ED13, which decreases transcriptional activation when combined with the Mediator comple, Xenopus/Amphibian,. The Mediator comple, Xenopus/Amphibian, is a large protein comple, Xenopus/Amphibian, composed of almost 30 different MED proteins that regulates transcription of nearly all RNA polymerase II (RNApII)-dependent genes, conveying information from gene-specific regulatory proteins. Mediator serves as a scaffold for the assembly of the functional preinitiation comple, Xenopus/Amphibian, that includes RNApII. Cyclin-C-bound CDK8 phosphorylates the C-terminal domain of the large subunit of RNApII, inhibiting the formation of a transcription initiation comple, Xenopus/Amphibian,. Cyclin-C is phosphorylated upon DNA damage,Porcinerobably by ATM or ATR.