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CUEDC2 Antibody (OAPB00767)

CUEDC2 Antibody (OAPB00767)

The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-kappaB by decreasing the activation of IKK. CUEDC2 antibody will not cross-react with CUEDC1.

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SPECIFICATIONS

Size

0.1 mg

Applications

ELISA, ICC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Presku

OAPB00767

Target

CUE Domain-Containing Protein 2

Alternative Names

CUEDC2; CUE Domain-Containing Protein 2

SUPPLIER INFO

Aviva Systems Biology Incorporated

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